KMID : 0869220180220020070
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Journal of Korean Geriatric Psychiatry 2018 Volume.22 No. 2 p.70 ~ p.75
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Anxiety Symptoms are Associated with Progression to Dementia in Patients with Amyloid-Positive Mild Cognitive Impairment
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Kim Hee-Seok
Jhoo Jin-Hyeong Jang Jae-Hoon
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Abstract
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Objective£ºAnxiety is prevalent in patients with mild cognitive impairment (MCI) and are considered to be a risk factor for conversion to dementia. The purpose of this study was to evaluate whether Anxiety symptoms in MCI promote disease progression in a manner related to amyloid status, and to determine the relationship between anxiety symptoms and longitudinal cerebral structural changes.
Methods£ºBaseline data for 230 patients with amyloid-positive MCI (52 with anxiety and 178 without) from the Alzheimer¡¯s Disease Neuroimaging Initiative study were analyzed. All participants underwent comprehensive cognitive testing, volumetric MRI, and [18F]AV45 positron emission tomography amyloid imaging. Anxiety symptoms were measured using the Neuropsychiatric Inventory Questionnaire. A voxel-based morphometric analysis using volumetric brain MRI data was used to compare longitudinal structural changes related to anxiety symptoms.
Results£ºThe conversion rate to dementia was different between patients with and without anxiety in amyloid-positive MCI (37.7% vs. 16.1%, respectively ; p=0.001). Anxiety in amyloid-positive MCI was associated with longitudinal cortical atrophy in the left superior temporal gyrus, left Heschl¡¯s gyrus, left parahippocampal gyrus, left anterior cingulum, bilateral anterior cingulum and right superior orbital gyrus.
Conclusion£ºOur study indicates that the presence of anxiety in patients with amyloid-positive MCI is associated with higher conversion to dementia and longitudinal cortical atrophy.
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KEYWORD
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Mild cognitive impairment, Alzheimer¡¯s disease, Anxiety
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